Louis van Gaal's side sit top of the group and can further their chances of reaching the knock-out stages with a win over the Dutch champions
Juan Mata has his sights set on top spot in Champions League Group B, even thoughManchester United are still to secure their place in the last 16 ahead of their clash with PSV on Wednesday.
Louis van Gaal's men go into the game at Old Trafford in pole position in the pool with seven points from four matches, although PSV and Wolfsburg are close behind on six, with CSKA Moscow bottom on four.
That means a win for United over PSV would seal qualification for the knockout rounds, but Mata has his sights set higher in a week that also sees Van Gaal's team travel to surprise Premier League leaders Leicester City.
"We could make an important step to finish first in our group in the Champions League and we could climb to the top of the Premier League - this is how we face this new week," Spain international Mata wrote on his blog for United's official website.
"We are feeling optimistic, as always, and our goal is to win both games and to have the best possible start to the busy period ahead.
"Obviously it is going to be tough and we will need to be at our highest level to beat PSV and Leicester. But let's go little by little.
"It is time for another Champions League night at Old Trafford against PSV Eindhoven. We lost there in the first week and now we want to get the three points that would take us closer to the next stage."
Juan Mata has his sights set on top spot in Champions League Group B, even thoughManchester United are still to secure their place in the last 16 ahead of their clash with PSV on Wednesday.
Louis van Gaal's men go into the game at Old Trafford in pole position in the pool with seven points from four matches, although PSV and Wolfsburg are close behind on six, with CSKA Moscow bottom on four.
That means a win for United over PSV would seal qualification for the knockout rounds, but Mata has his sights set higher in a week that also sees Van Gaal's team travel to surprise Premier League leaders Leicester City.
"We could make an important step to finish first in our group in the Champions League and we could climb to the top of the Premier League - this is how we face this new week," Spain international Mata wrote on his blog for United's official website.
"We are feeling optimistic, as always, and our goal is to win both games and to have the best possible start to the busy period ahead.
"Obviously it is going to be tough and we will need to be at our highest level to beat PSV and Leicester. But let's go little by little.
"It is time for another Champions League night at Old Trafford against PSV Eindhoven. We lost there in the first week and now we want to get the three points that would take us closer to the next stage."
United have been struggling with injuries, although Van Gaal hopes to have captain Wayne Rooney back from illness. Late checks will be made on Anthony Martial, Michael Carrick and Marouane Fellaini, but Phil Jones and Ander Herrera are expected to miss out.
LAST FIVE MATCHES
HEAD TO HEAD
Manchester United
PSV
Manchester United captain Wayne Rooney is fit for Wednesday's Champions League clash with PSV Eindhoven but may not start, says manager Louis van Gaal.
Rooney trained on Tuesday after missing Saturday's 2-1 win over Watford with illness.
But asked if Rooney would regain his place in the XI, Van Gaal said: "No, not automatically."
Striker Anthony Martial is also fit, but midfielder Ander Herrera and defender Phil Jones are unavailable.
Marouane Fellaini, who also missed the Watford match, has recovered from a calf injury.
But Van Gaal said the Belgian midfielder, Martial and Rooney would have to "show on the training ground" that they deserved a starting place for the Group B match.
Group B leaders United will progress to the knockout stage with victory, though PSV will have other ideas as they seek the win that could take them top of the section instead.
United were beaten 2-1 in Eindhoven in the reverse fixture and Van Gaal described that match as "very disappointing", not just because of the result but also because of the loss of Luke Shaw to a broken leg.
"For me and for us he is a very important player," Van Gaal said. "I said in advance that he would be the revelation of this season and he was on his way to doing that."
The United manager revealed that he has given Shaw some time off this week from his recovery routine.
"Shaw was fed up with the daily routine and I saw why he was fed up, maybe because it was PSV," Van Gaal said.
The England international will have a scan on Friday to see how his leg is recovering.
Midfielders Antonio Valencia and Michael Carrick also remain unavailable for United.
Manchester United vs PSV Eindhoven
PSV Eindhoven predicted XI (4-3-3): Zoet; Arias, Moreno, Bruma, Brenet; Propper, Hendrix, Guardado; Narsingh, De Jong, Locadia.
Manchester United predicted XI (4-2-3-1): De Gea; Darmian, Smalling, Blind, Rojo; Schneiderlin, Schweinsteiger; Lingard, Rooney, Depay; Martial.
The game will be extra special for Memphis Depay as he joined United from PSV in the summer, so he will go through the emotions, but after scoring in Eindhoven he will be hoping to score again against his former club to help his new team qualify for the next round of the Champions League.
The last time PSV visited Old Trafford was back in the 2000/01 season when they lost 3-1, and a repeat of that result for United would be great for them, but PSV will be confident as they lead the head to head 2-1 over three meetings with United.
Van Gaal knows the importance of the game against PSV on Wednesday, and especially as it's at Old Trafford as he feels "it is a stadium that has the highest inspiration" meaning when a player steps on the pitch at Old Trafford it's extra special.
PSV go into the game with a couple of injuries with both Jetro Willems and Menno Koch both ruled out with long term injuries, while Hector Moreno, Maxime Lestienne and Simon Pulsonare all doubts for the game.
United go into the game with five players missing including Shaw,Antonio Valencia, Michael Carrick, Phil Jones and Ander Herrera, but Wayne Rooney, Anthony Martial and Maroaune Fellaini are back and available for the game. Bastian Schweinsteiger missed training as he was given the day off to recover, but there's no reason he can't play.
Champions League Live Score 2015
PSV drew 2-2 at the weekend in the Eridvisie against Willem IIwhich was the only game they have dropped any points in during their last five games, and have been free scoring during this time, withLuuk De Jong their key man scoring plenty, and is someone United will have to be well aware of on Wednesday night.
United come into the game versus PSV in good form having won 3 in a row with the recent win a 2-1 win at the weekend away at Watford, and before the International break they had won 2 in a row as well, and United will be confident of adding to the run of victories on Wednesday.
Louis van Gaal gave an update on Shaw's injury at his pre match press conference saying that the defender was due to have another scan on Friday to see how his recovery from injury is progressing.
The game at Old Trafford will be the first game between the two clubs since the horrific injury that Luke Shaw obtained from a Hector Moreno tackle in Eindhoven in September, and the PSV defender could be in for some rough treatment from the Old Trafford crowd on Wednesday night.
Manchester United vs PSV Eindhoven Live Stream
PSV meanwhile are second in group B after defeating Wolfsburg 2-0 in their last match, and will be confident going into the match against United after defeating them in match day one 2-1 in Holland, and will have high hopes they can pull of a shock at Old Trafford.
United go into the Champions League, match with PSV currently top of group B after winning their last match at home versus CSKA Moscow, and can secure qualification for the round of 16 with a win against PSV.
Manchester United v PSV: MEN writers pick their starting XIs
Our writers have their say on who should start for Man Utd in their Champions League game, while there's still time to have your say.
Rob Dawson
With Phil Jones out Louis van Gaal hasn't got many other options at the back. Daley Blind is likely to take his place with Marcos Rojo at left-back.
Matteo Darmian had a bit of a nightmare in the first game against PSV but Ashley Young had a difficult day defensively against Watford.
If Wayne Rooney and Anthony Martial are fully fit they should start because it's a game United have to win.
It might be time to give Juan Mata a break with Jesse Lingard and Memphis Depay out wide.
Rob's team: De Gea, Darmian, Rojo, Smalling, Blind, Schneiderlin, Schweinsteiger, Lingard, Memphis, Rooney, Martial.
Rob's prediction: United 3 PSV 1
James Robson
After his impressive performance against Watford, I'd be tempted to see Memphis Depay given another run up front, with Wayne Rooney playing in the No.10 role.
Van Gaal likes Anthony Martial on the left and - if fit, following his foot injury - he provides United with a fluid forward line that can interchange when necessary.
Jesse Lingard's recent form means it would be a big call to leave him out.
With so many injury concerns, it is a case of which players Van Gaal can get onto the pitch.
James' team: De Gea, Darmian, Smalling, Blind, Rojo, Schneiderlin, Schweinsteiger, Lingard , Rooney, Martial, Depay
James' prediction: United 2 PSV 0
Simon Bajkowski
Injuries have ravaged Van Gaal's team, meaning the first seven names on the teamsheet - and the formation - pick themselves.
Morgan Schneiderlin and Bastian Schweinsteiger are essential to the way United will set up tonight in the 4-2-3-1 that the manager has favoured for most of the season.
With Wayne Rooney and Anthony Martial back for this game, the time could be right to get back on with the experiment of the captain playing in the role of a supporting striker.
Memphis scored from a central position at Watford but his best moments for United have come in this competition on the left.
Simon's team: De Gea, Darmian, Smalling, Blind, Rojo, Schneiderlin, Schweinsteiger, Mata, Rooney, Memphis, Martial
Simon's prediction: United 2 PSV 1
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